Internal Med Medical News about Pulmonary Disease, Chronic Obstructive Fluticasone

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Effect of Fluticasone With and Without Salmeterol on Pulmonary Outcomes in Chronic Obstructive Pulmonary Disease
Annals of Internal Medicine, 10/20/09

Lapperre TS et al. – This randomized trial compared treatment with fluticasone for 6 months, fluticasone for 30 months, fluticasone and salmeterol for 30 months, or placebo in steroid–naive patients who had COPD, most of whom had airway hyperresponsiveness. Investigators found reduced inflammatory cells in sputum and bronchial biopsies and attenuated decrease in lung function during fluticasone treatment. Adding salmeterol did not further alter the decrease in lung function. Steroids not only reduce inflammation but can also slow decrease in lung function in some subphenotypes of steroid–naive patients with COPD.

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Parasternal muscle activity decreases in severe COPD with salmeterol-fluticasone propionate
Chest, 10/20/09 Relevance Score: 92%

Effect of Fluticasone Propionate/Salmeterol (250/50) on COPD Exacerbations and Impact on Patient Outcomes
COPD: Journal of Chronic Obstructive Pulmonary Disease, 10/06/09 Relevance Score: 92%

Increased relative mortality in women with severe oxygen-dependent chronic obstructive pulmonary disease
Chest, 10/07/09 Relevance Score: 90%

Increased relative mortality in women with severe oxygen-dependent chronic obstructive pulmonary disease
Chest, 10/05/09 Relevance Score: 90%

The immediate effect of individual manipulation techniques on pulmonary function measures in persons with chronic obstructive pulmonary disease
Internet Source, 10/09/09 Relevance Score: 89%