Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Recommendations on the use of 18F-FDG PET in oncology 3. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 4. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease 5. Rapid correction of low vitamin D status in nursing home residents
Top Ten Searches
etanercept hypertension chf antiphospholipid fibrosis mrsa scid renal cell rickets counterpulsationYour Article Summary
See Latest ArticlesEffects of Aging on Pharmacokinetic and Pharmacodynamic Drug Processes
Journal of Psychosocial Nursing and Mental Health Services, 10/26/09
Howland RH – Aging affects the pharmacokinetics and pharmacodynamics of drugs, which has potentially important implications for the use of psychotropic medication in older adults. The absorption of orally administered drugs may be impaired or delayed, the volume of distribution of most drugs is decreased, and over time, the distribution shifts toward greater drug accumulation in fat stores. Decrease in renal function with age is especially important regarding the use of lithium but is also relevant for most drugs because they are eventually cleared through the kidneys after metabolism in the liver. Because pharmacodynamic changes associated with aging will make elderly patients more sensitive to the pharmacological effects of medication—especially adverse effects—nurses should be appropriately trained in pharmacology and therapeutics in older adults.
Related Articles
Space, Gravity and the Physiology of Aging: Parallel or Convergent Disciplines? A Mini-Review
Gerontology, 10/26/09
Relevance Score: 90%
Is androgen therapy indicated for aging men?
Sexuality, Reproduction & Menopause, 10/05/09
Relevance Score: 89%
Regional pattern of white matter microstructural changes in normal aging, MCI, and AD
Neurology, 10/30/09
Relevance Score: 87%
Prostate Volume Changes Over Time: Results From the Baltimore Longitudinal Study of Aging
The Journal of Urology, 10/01/09
Relevance Score: 87%
Specific repair of aging hair keratin
International Journal of Cosmetic Science, 11/03/09
Relevance Score: 85%
Today in Geriatrics...keeping you current
Receive free subspecialty "5-minute updates" via email
Effect of Raloxifene on Serum Lipids for Type 2 Diabetic Menopausal Women with or without Statin Treatment
Medical Principles and Practice, 12/10/09
Obesity in older adults: relationship to functional limitation
Current Opinion in Clinical Nutrition & Metabolic Care, 12/10/09
Protecting muscle mass and function in older adults during bed rest
Current Opinion in Clinical Nutrition & Metabolic Care, 12/10/09
Sponsor
Article Search
Sponsor
Sponsor