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Risk factors for development of coronary artery disease in women with systemic lupus erythematosus
Journal of Rheumatology, 10/19/09

Goldberg RJ et al. – In a prospective study of patients with SLE and matched controls followed over a median of 8 years, patients with SLE developed significantly more CAD events than controls. Accounting for demographic variability, CAD risk factors, and lipid factors, SLE is an independent risk factor for the development of CAD.

Methods

SLE patients and non-SLE age-matched controls without a history of CAD recruited into prospective study between 1997 and 1999
CAD events assessed at clinic visit for SLE patients and through telephone interview and chart review for controls
All events verified with medical records

Results

Followup information available on 237 controls and 241 SLE patients
Mean followup time was 7.2 years
Univariate analyses identified age and postmenopausal status as predictors of CAD in both groups
Sedentary lifestyle, hypertension, the presence of metabolic syndrome, and the number of Framingham risk factors predictive in control group only
10-year risk of CAD score predictive in both groups but not as marked in SLE group as in controls
Lipid subfractions not predictive for CAD in SLE group
In controls, high triglyceride level ≥ 2.8 predictive
Time-to-event multivariate analysis for CAD in all subjects revealed SLE , older age, and triglycerides ≥ 2.8 to be highly predictive for CAD