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Autoantibodies and the risk of cardiovascular events
Journal of Rheumatology, 10/19/09

Liang KP et al. – RF and ANA positivity are significant predictors of CV events and mortality in both those with and those without rheumatic diseases. These results support the role of immune dysregulation in the etiology of CV disease.

Methods

Population-based cohort study
Subjects had RF and/or ANA test performed between January 1, 1990, and January 1, 2000, and/or CCP test performed between September 1, 2003, and January 1, 2005, with followup until April 1, 2007
Outcomes ascertained using diagnostic indices from complete medical records, including CV events (MI, HF, and PVD) and mortality
Cox models used to analyze data

Results

6783 subjects with RF, 7852 with ANA, and 299 with CCP testing
Adjusting for age, sex, calendar year, comorbidity, and rheumatic disease, RF and ANA positivity were significant predictors of CV events and death
Adjusting for age, CCP positivity associated with CV events, but this association not statistically significant

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