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Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study
Annals of Oncology, 10/16/09

Mar Fan HG et al. – Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.

• 41 women who had undergone menopause as result of chemotherapy and 57 healthy women who had undergone recent natural menopause evaluated on 2 occasions 1 year apart
• Primary end point was summed score of self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale
• Quality of life evaluated by FACT-G questionnaire and fatigue by FACT-F subscale

• Strong trend for patients to report worse FACT-ES scores than controls at first and second time points
• More patients had moderate/severe hot flashes than controls undergoing natural menopause (51% versus 19%)
• Patients reported worse fatigue than controls at first assessment , with no difference at the second
• Menopausal symptoms associated with fatigue for both groups
• No difference between patients and controls in quality-of-life scale

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