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See Latest ArticlesIncidence and causes of heparin-induced skin lesions
Canadian Medical Association Journal, 10/19/09
Schindewolf M et al. – Heparin–induced skin lesions are relatively common, have identifiable risk factors and are commonly caused by a delayed–type hypersensitivity reaction (type IV allergic response).
Methods- The authors prospectively examined consecutive patients who received subcutaneous heparin (most often enoxaparin or nadroparin) for the presence of heparin–induced skin lesions.
- If such lesions were identified, the authors performed a skin biopsy, platelet count measurements, and antiplatelet–factor 4 antibody and allergy testing.
- The authors enrolled 320 patients.
- In total, 24 patients (7.5%, 95% confidence interval [CI] 4.7%–10.6%) had heparin–induced skin lesions.
- Delayed–type hypersensitivity reactions were identified as the cause in all 24 patients.
- One patient with histopathologic evidence of delayed–type hypersensitivity tested positive for antiplatelet–factor 4 antibodies.
- The authors identified the following risk factors for heparin–induced skin lesions: a body mass index greater than 25, duration of heparin therapy longer than 9 days and female sex.
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Today in Dermatology...keeping you current
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Acute Generalized Exanthematous Pustulosis: A Rare Clinical Entity With Use of Piperacillin/Tazobactam
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Interferon-gamma (INF-gamma) release test can detect cutaneous adverse effects to statins
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