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Cutaneous vasculitis induced by TNF inhibitors: a report of three cases
Modern Rheumatology, 10/16/09

Fujikawa K et al. – We describe 3 rheumatoid arthritis (RA) patients with anti-tumor necrosis factor (TNF) therapy-induced cutaneous vasculitis. Two patients required oral corticosteroid, the efficacy of which was observed to be excellent and rapid.

Methods

3 RA patients with anti-tumor necrosis factor (TNF) therapy-induced cutaneous vasculitis
2 cases induced by infliximab
3rd case (cutaneous vasculitis found early at start of therapy) induced by etanercept
Skin biopsy obtained in 2 patients

Results

Histology-proven leukocytoclastic vasculitis in 2 patients
1 patient spontaneously improved after cessation of TNF inhibitor
2 patients required oral corticosteroid, efficacy of which was observed to be excellent and rapid

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