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See Latest ArticlesUrinary 6-Sulphatoxymelatonin Levels Are Depressed in Chronic Migraine and Several Comorbidities
Headache: The Journal of Head and Face Pain, 10/12/09
Masruha MR et al. – A total of 220 subjects were evaluated – 73 (33%) had episodic migraine, 73 (33%) had chronic migraine, and 74 (34%) were enrolled as control subjects. There was a strong correlation between the concentration of 6–sulphatoxymelatonin detected and chronic migraine. Regarding the comorbidities, this study objectively demonstrates an inverse relationship between 6–sulphatoxymelatonin levels and depression, anxiety, and fatigue. To the authors' knowledge, this is the first study to evaluate the relationship between the urinary concentration of melatonin and migraine comorbidities. These results support hypothalamic involvement in migraine pathophysiology.
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