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Panettieri Jr RA et al. – In these subjects with moderate to severe COPD, single–day administrations of ARF15 BID or ARF30 QD were associated with FEV1 responses over a period of 24 hours that were considered equivalent per the protocol definition employed in the present study. FEV1 improvement over 12 hours was greater for ARF30 QD after the morning dose and for ARF15 BID after the evening dose.

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