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Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database
Osteoporosis International, 10/12/09

Breart G et al. – This study shows a greater association of VTE in osteoporotic compared to non-osteoporotic patients, but does not show any greater association in treated patients with strontium ranelate or alendronate compared to untreated osteoporotic patients.

Methods

Retrospective study
Cohorts consisted of untreated osteoporotic women (N?=?11,546), osteoporotic women treated with alendronate (N?=?20,084), or strontium ranelate (N?=?2,408), and sample of non-osteoporotic women (N?=?115,009)
Cohorts compared using Cox proportional hazards regression model

Results

Significantly increased relative risk for VTE in untreated osteoporotic women versus non-osteoporotic women (annual incidence 5.6 and 3.2 per 1,000 patient–years
Results confirmed using adjusted models
Annual incidences of VTE in osteoporotic patients treated with strontium ranelate and alendronate were 7.0 and 7.2 per 1,000 patient–years
No significant difference between untreated and treated patients whatever the treatment
Adjusted hazard ratios for treated versus untreated osteoporotic women 1.09 (95% CI, 0.60–2.01) for strontium ranelate and 0.92 (95% CI, 0.63–1.33) for alendronate