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Marti–Carvajal AJ et al. – In this review the authors included eight randomised controlled trials equivalent to 24,210 participants. The authors found no evidence that homocysteine–lowering interventions, in the form of supplements of vitamins B6, B9 or B12 given alone or in combination, at any dosage compared with placebo or standard care, prevents myocardial infarction, stroke, or reduces total mortality in participants at risk or with established cardiovascular disease.

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