Internal Med Medical News about Arthritis, Rheumatoid Biological Products

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Biologics for rheumatoid arthritis: an overview of Cochrane reviews
Cochrane Reviews, 10/09/09

Singh JA et al. – Based upon indirect comparisons, anakinra seemed less efficacious than etanercept, adalimumab and rituximab and etanercept seemed to cause fewer withdrawals due to adverse events than adalimumab, anakinra and infliximab. Significant heterogeneity in characteristics of trial populations imply that these finding must be interpreted with caution. These findings can inform physicians and patients regarding their choice of biologic for treatment of RA.

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Proinflammatory cytokines synergistically enhance the production of chemokine ligand 20 (CCL20) from rheumatoid fibroblast-like synovial cells in vitro and serum CCL20 is reduced in vivo by biologic disease-modifying antirheumatic drugs
Journal of Rheumatology, 10/05/09 Relevance Score: 90%

Abatacept for rheumatoid arthritis
Cochrane Reviews, 10/09/09 Relevance Score: 83%

ACR70-disease activity score remission achievement from switches between all the available biological agents in rheumatoid arthritis: a systematic review of the literature
Arthritis Research & Therapy, 11/17/09 Relevance Score: 82%

Assistive technology for rheumatoid arthritis
Cochrane Reviews, 10/09/09 Relevance Score: 82%

Pattern and predictors of the initiation of biologic agents for the treatment of rheumatoid arthritis in the United States: An analysis using a large observational data bank
Clinical Therapeutics, 10/16/09 Relevance Score: 81%