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Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients
Journal of Clinical Rheumatology (JCR), 10/08/09

van Wietmarschen H et al. – RA patients could be divided in 2 groups according to CM theory. Molecular differences between the RA Cold and RA Heat groups were found which suggest differences in apoptotic activity. Subgrouping of patients according to CM diagnosis has the potential to provide opportunities for better treatment outcomes by targeting Western or CM treatment to specific groups of patients

Methods

Blood samples of 33 RA patients and 16 healthy volunteers collected
RA patients diagnosed according to Chinese medicine (CM) theory and divided into 2 groups, the RA Heat and RA Cold group
CD4+ T-cells were used for a total gene expression analysis
Metabolite profiles measured in plasma using gas chromatography/mass spectrometry
Multivariate statistics employed to find potential biomarkers for the RA Heat and RA Cold phenotype
Comprehensive biologic interpretation of results is discussed

Results

Genomics and metabolomics analysis showed statistically relevant different gene expression and metabolite profiles between healthy controls and RA patients as well as between the RA Heat and RA Cold group
Differences found in regulation of apoptosis
In RA Heat group caspase 8 activated apoptosis seems stimulated while in RA Cold group apoptosis seems suppressed through the Nrf2 pathway

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