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Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk
International Journal of Epidemiology, 10/08/09

Marron M et al. – These results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer.

Methods

The authors pooled individual–level data from case–control studies in the International Head and Neck Cancer Epidemiology Consortium.
Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls).
The authors estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models.

Results

Quitting tobacco smoking for 1–4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61–0.81 compared with current smoking], with the risk reduction due to smoking cessation after >=20 years (OR 0.23, CI 0.18–0.31), reaching the level of never smokers.
For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after >=20 years of quitting (OR 0.60, CI 0.40–0.89 compared with current drinking), reaching the level of never drinkers.

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