Internal Med

Your Article Summary

See Latest Articles

Effectiveness of rosuvastatin in reducing LDL-C and target LDL-C goal attainment in real-world clinical practice
Current Medical Research and Opinion, 10/22/09

Gandhi SK et al. – There is a strong and consistent body of evidence demonstrating the effectiveness of rosuvastatin in lowering LDL–C and LDL–C goal attainment in real life compared with other statins at commonly prescribed doses, which reflects the existing evidence from clinical trials.

• A comprehensive Medline literature search identified all published articles, in all languages, from January 2003 through September 2008 on the use of rosuvastatin in the usual–care setting.
• The search identified 60 articles, and 16 articles were included in this review because they were observational and non–interventional and included sufficient data specific to rosuvastatin.
• Excluded articles were clinical trials, cost–effectiveness models, safety, reviews, pharmacokinetics, abstracts or editorials only, or all statins combined.
• Included rosuvastatin articles were categorized as (1) effectiveness in general population and (2) effectiveness in special populations (e.g., elderly, diabetes).

• 7 studies consistently showed that diverse patients from different geographic regions who were newly initiated on rosuvastatin had significantly greater reduction in low–density lipoprotein cholesterol (LDL–C) (29–52%) compared with patients treated with other statins (16–43%).
• LDL–C goal attainment as recommended by National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III was consistently and significantly higher among patients treated with rosuvastatin (64–81%) compared with patients treated with other statins (34–73%).
• Rosuvastatin–treated patients with diabetes or HIV or who were elderly had significantly greater LDL–C reduction and LDL–C goal attainment compared with patients treated with other statins.
• Limitations: channeling bias or confounding by indication may have influenced the results of the real–world studies, if physicians reserve rosuvastatin for sicker or more difficult to treat patients.

Today in Atherosclerosis/Lipids...keeping you current

Receive free subspecialty "5-minute updates" via email

Effects of Combination Lipid Therapy on Coronary Stenosis Progression and Clinical Cardiovascular Events in Coronary Disease Patients With Metabolic Syndrome: A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), and the Armed Forces Regression Study (AFREGS)
The American Journal of Cardiology, 12/02/09

Low bone mineral density is not associated with angiographically determined coronary atherosclerosis in men
Osteoporosis International, 12/01/09

Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review
American Journal of Clinical Nutrition, 12/01/09

 See all of Atherosclerosis/Lipids

Today in Cardiology...keeping you current

Receive free subspecialty "5-minute updates" via email

Impact of Strength and Resistance Training on Cardiovascular Disease Risk Factors and Outcomes in Older Adults
Clinics in Geriatric Medicine, 12/02/09

Effectiveness of Public Report Cards for Improving the Quality of Cardiac Care: The EFFECT Study: A Randomized Trial
JAMA, 12/02/09

Effects of Combination Lipid Therapy on Coronary Stenosis Progression and Clinical Cardiovascular Events in Coronary Disease Patients With Metabolic Syndrome: A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), and the Armed Forces Regression Study (AFREGS)
The American Journal of Cardiology, 12/02/09

 See all of Cardiology

Today in Clinical Pharmacology...keeping you current

Receive free subspecialty "5-minute updates" via email

When Opioids Have Been Prescribed for Chronic Pain
Journal Of Pain & Palliative Care Pharmacotherapy, 12/02/09

Impaired Renal Function and Opioid Toxicity
Journal Of Pain & Palliative Care Pharmacotherapy, 12/02/09

Expand the Pharyngitis Paradigm for Adolescents and Young Adults
Annals of Internal Medicine, 12/02/09

 See all of Clinical Pharmacology