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Metformin restores impaired HDL-mediated cholesterol efflux due to glycation
Atherosclerosis, 10/07/09
Matsuki K et al. – Glycated HDL particles are ineffective as acceptors of ABCG1–mediated cholesterol efflux; and this may explain, at least in part, accelerated atherosclerosis in diabetic patients. Metformin serves as a possible candidate to restore impaired cholesterol efflux and reverse cholesterol transport.
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