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See Latest ArticlesCorrelation between MMP-13 and HDAC7 expression in human knee osteoarthritis
Modern Rheumatology, 10/05/09
Higashiyama R et al. – Elevated HDAC7 expression in human OA may contribute to cartilage degradation via promoting MMP-13 gene expression, suggesting the critical role of MMP-13 in OA pathogenesis.
Methods- Correlation between HDACs and MMP-13 investigated
- Expression of different HDACs in cartilage from OA patients and healthy donors compared
- HDAC7 showed significant elevation in cartilage from OA patients
- High level of HDAC7 expression in OA cartilage also confirmed by immunohistochemistry
- Knockdown of HDAC7 by small interference RNA (siRNA) in SW1353 human chondrosarcoma cells strongly suppressed interleukin (IL)-1-dependent and independent induction of MMP-13 gene expression
Today in Orthopedic/Physical Med...keeping you current
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Effect of alendronate on bone metabolic indices and bone mineral density in patients treated with high-dose glucocorticoid: A prospective study
Osteoporosis International, 11/25/09
Prevalent vertebral deformity independently increases incident vertebral fracture risk in middle-aged and elderly Japanese women: The Japanese Population-based Osteoporosis (JPOS) Cohort Study
Osteoporosis International, 11/25/09
Chronic Musculoskeletal Pain and the Occurrence of Falls in an Older Population
JAMA, 11/25/09
Today in Rheumatology...keeping you current
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Effect of alendronate on bone metabolic indices and bone mineral density in patients treated with high-dose glucocorticoid: A prospective study
Osteoporosis International, 11/25/09
Treatment of osteoporosis: Recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity
Osteoporosis International, 11/25/09
Prevalent vertebral deformity independently increases incident vertebral fracture risk in middle-aged and elderly Japanese women: The Japanese Population-based Osteoporosis (JPOS) Cohort Study
Osteoporosis International, 11/25/09
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