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Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP Diet and Health Study
BMC Cancer, 10/05/09

Peters TM et al. – A high level of recent, but not historical, physical activity of moderate-to-vigorous intensity is associated with reduced postmenopausal breast cancer risk. More precise recall of recent physical activity than activity in the distant past is one possible explanation for our findings

Methods

118,899 postmenopausal women
Examined relations of light and moderate-to-vigorous intensity physical activity during four periods of life ("historical": ages 15-18, 19-29, 35-39 years; "recent": past 10 years) to postmenopausal breast cancer risk
Physical activity assessed by self-report at baseline, and 4287 incident breast cancers identified over 6.6 years of follow-up

Results

In age-adjusted and multivariate Cox regression models, >7 hours/week of moderate-to-vigorous activity during the past 10 years associated with 16% reduced risk of postmenopausal breast cancer (RR:0.84; 95%CI:0.76,0.93) compared with inactivity
Association remained statistically significant after adjustment for BMI
Neither moderate-to-vigorous intensity activity during other periods of life nor light intensity activity during any period of life related to breast cancer risk, and associations did not vary by tumor characteristics

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