Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Recommendations on the use of 18F-FDG PET in oncology 3. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 4. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease 5. Rapid correction of low vitamin D status in nursing home residents
Top Ten Searches
etanercept hypertension chf antiphospholipid fibrosis mrsa scid renal cell rickets counterpulsationYour Article Summary
See Latest ArticlesEffective anti-tnf-î± therapy can induce rapid resolution and sustained decrease of gastroduodenal mucosal amyloid deposits in reactive amyloidosis associated with rheumatoid arthritis
Journal of Rheumatology, 10/09/09
Kuroda T et al. –This study examined the effect of anti-tumor necrosis factor-? (anti-TNF) therapy in patients with reactive AA amyloidosis associated with RA. Our results indicate a striking effect of anti-TNF therapy for rapid removal and sustained disappearance of amyloid deposits in gastric mucosal tissue with amelioration of renal functions in patients with reactive amyloidosis due to RA
Methods- 14 patients with reactive AA amyloidosis associated with RA were prospectively evaluated
- Mean period of anti-TNF therapy 20.1 ± 13.8 mos
- Laboratory findings and renal function examined before and after initiation of anti-TNF therapy
- In 9 patients area of amyloid deposits in serial gastroduodenal mucosal biopsy specimens examined and image analysis performed
- C-reactive protein and serum amyloid A protein levels significantly reduced after initiation of anti-TNF therapy
- 24 hour creatinine clearance improved in 4 patients, did not change in 5, and deteriorated in 3
- Biopsy specimens from 9 patients who underwent serial gastroduodenal biopsies showed significant decreases in area of amyloid deposits, from 8.8% ± 6.4% to 1.6% ± 0.6% (p = 0.003) after initiation of anti-TNF therapy
- 4 patients showed sustained decrease in areas of amyloid deposits in third biopsy specimens, and amyloid deposits not detectable in 2
Today in Rheumatology...keeping you current
Receive free subspecialty "5-minute updates" via email
Denuded subchondral bone and knee pain in persons with knee osteoarthritis
Arthritis & Rheumatism, 12/04/09
Continuing Medical Education Challenges in Chronic Fatigue Syndrome
BMC Medical Education, 12/04/09
Increased mRNA expression of collagen V gene in pulmonary fibrosis of systemic sclerosis
European Journal of Clinical Investigation, 12/04/09
Sponsor
Article Search
Sponsor
Sponsor