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Aged garlic extract supplemented with B vitamins, folic acid and l-arginine retards the progression of subclinical atherosclerosis: A randomized clinical trial
Preventive Medicine, 10/07/09

Budoff MJ et al. – Aged garlic extract therapy with supplements (AGE + S) is associated with a favorable improvement in oxidative biomarkers, vascular function, and reduced progression of atherosclerosis.

Methods

In this placebo–controlled, double–blind, randomized trial (conducted 2005–2007), 65 intermediate risk patients (age 60 ± 9 years, 79% male) were treated with a placebo capsule or a capsule containing aged garlic extract (250 mg) plus Vitamin B12 (100 microg), folic acid (300 microg), Vitamin B6 (12.5 mg) and l–arginine (100 mg) given daily for a 1 year.
All patients underwent coronary artery calcium scanning (CAC), temperature rebound (TR) as an index of vascular reactivity using Digital Thermal Monitoring (DTM), and measurement of lipid profile, autoantibodies to malondialdehyde (MDA)–LDL, apoB–immune complexes, oxidized phospholipids (OxPL) on apolipoprotein B–100 (OxPL/apoB), lipoprotein (a) [Lp (a)], C–reactive protein (CRP), homocysteine were measured at baseline and 12 months.
CAC progression was defined as an increase in CAC > 15% per year and an increase in TR above baseline was considered a favorable response.

Results

At 1 year, CAC progression was significantly lower and TR significantly higher in the AGE + S compared to the placebo group after adjustment of cardiovascular risk factors.
Total cholesterol, LDL–C, homocysteine, IgG and IgM autoantibodies to MDA–LDL and apoB–immune complexes were decreased, whereas HDL, OxPL/apoB, and Lp (a) were significantly increased in AGE + S to placebo.