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Micro-CT and mechanical evaluation of subchondral trabecular bone structure between postmenopausal women with osteoarthritis and osteoporosis
Osteoporosis International, 09/29/09

Zhang ZM FI et al. – We observed the difference in microstructure between postmenopausal women with OA and OP, which might relate to the opposite bone defects in OA and OP. BV/TV might play an important role in mechanical properties of the subchondral bone in either OA or OP.

Methods

Femoral head specimens obtained from 17 postmenopausal women during hip surgery
Microstructural parameters measured with micro-CT
Mechanical test performed after bone cube scanning

Results

Significant difference in bone volume fraction (BV/TV) and trabecular thickness noted between OA and OP groups
Structure model index decreased in OA; increased in OP
Higher apparent density (AD) and lower material density (MD) shown in OA
Positive correlation were noted between connectivity density and mechanical indices in OA
In OA group, BV/TV associated with Young’s modulus and AD, while trabecular number only parameter correlated with MD
In OP group, only BV/TV correlated with yield strength, AD, and MD

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