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See Latest ArticlesIndependent from muscle power and balance performance, a creatinine clearance below 65 ml/min is a significant and independent risk factor for falls and fall-related fractures in elderly men and women diagnosed with osteoporosis
Osteoporosis International, 09/29/09
Dukas L et al. – In this study, we found a significant gender-independent correlation between decreasing CrCl and lower performance in balance and muscle power tests. Reduced muscle power and balance may therefore be involved in the low creatinine clearance associated increased risk for falls and fall-related fractures. Furthermore, we found that a CrCl <65 ml/min., independent from the performance in muscle power, muscle function, and balance tests, is a significant risk factor for falls and fractures.
Methods- Cross-sectional-study
- 1781 German osteoporotic patients
- Association between the CrCl, the physical performance, and the number of falls and fractures assessed
- Controlling for age, gender, BMI, and osteoporosis treatment (fracture analysis only), a decreasing CrCl was associated with lower physical performance in the timed-up-and-go test (corr ?0.2337), chair-rising test (corr ?0.1706),and tandem-stand test (corr 0.2193, ), and a CrCl of <65 ml/min was associated with a significantly higher risk for falls (47.7% vs. 36.2%, ) and fall-related fractures (33.1% vs. 22.9%, ) compared with a CrCl of ≥ 65 ml/min
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