Internal Med Medical News about single gene disorders

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Small-molecule signal transduction inhibitors: targeted therapeutic agents for single gene disorders
Journal of Medical Genetics, 09/25/09

Davies M et al. – The authors review recent examples of the use of small–molecule drugs to target components of signalling networks in single gene disorders. They also consider the limitations of these approaches and the difficulties in their clinical development as therapies for rare genetic diseases.

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Single Nucleotide Polymorphisms of the Serotonin Transporter Gene in Migraine – An Association Study
Headache: The Journal of Head and Face Pain, 10/26/09 Relevance Score: 80%

Beta-Thalassaemia prototype of a single gene disorder with multiple phenotypes
International Journal of Hematology, 10/12/09 Relevance Score: 80%

Nigrostriatal dysfunction in homozygous and heterozygous parkin gene carriers: An 18F-dopa PET progression study
Movement Disorders, 11/03/09 Relevance Score: 78%

Association study between GABA receptor genes and anxiety spectrum disorders
Depression and Anxiety, 10/23/09 Relevance Score: 67%

Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma
Cancer Causes and Control, 10/14/09 Relevance Score: 67%