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Vogiatzi G et al. – There is a large body of evidence connecting the effects of oxidative stress with atherogenesis. However, so far the authors have not determined a specific causative relation between oxidative events in general and oxidative modification of LDL in particular with respect to atherosclerosis. The existing clinical studies of the role of antioxidants according to specific endpoints are quite disappointing. It is therefore important, with the contribution of molecular cardiology andpharmacogenetics, to elucidate the molecules as well as the inhibiting mechanisms that interfere in the oxidative process.

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