Internal Med Medical News about Migraine Disorders Platelet Activation

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Platelet dysfunction and stroke in the female migraineur
Current Pain and Headache Reports, 09/21/09

Tietjen E et al. – Some studies suggest that platelet activation and aggregation are associated with migraine, likely secondary to changes occurring during the acute attack. Evidence also suggests that platelet clots can lodge in small cerebral vessels, and that the resultant is chemia and inflammation can induce cortical spreading depression with aura–like symptoms and pulsatile headache. Endothelial dysfunction, a result of numerous vascular, genetic, and environmental risk factors, is more common in women with migraine and leads to altered hemostasis. When associated with other factors, such as oral contraceptive use, there may be an increased tendency for thrombus formation, secondary migraine with aura, transient ischemic attacks, and stroke. Identifying those migraineurs at highest risk of developing endothelial dysfunction and platelet disorders may allow for preventive strategies to avoid the cerebral consequences.

Platelet functions beyond hemostasis
Journal of Thrombosis and Haemostasis, 10/29/09 Relevance Score: 80%

Management of bleeding and of invasive procedures in patients with platelet disorders and/or thrombocytopenia: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)
Thrombosis Research, 10/26/09 Relevance Score: 80%

Migraine presenting as chronic facial pain
Acta Neurologica Belgica, 10/16/09 Relevance Score: 80%

Capillary Endothelial Na+, K+, ATPase Transporter Homeostasis and a New Theory for Migraine Pathophysiology
Headache: The Journal of Head and Face Pain, 10/27/09 Relevance Score: 79%

Nephropathy in Type 1 diabetes is associated with increased circulating activated platelets and platelet hyperreactivity
Platelets, 10/30/09 Relevance Score: 69%