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See Latest ArticlesMeta-analysis: Retinal Vessel Caliber and Risk for Coronary Heart Disease
Annals of Internal Medicine, 09/15/09
McGeechan K et al. – Retinal vessel caliber changes were independently associated with an increased risk for CHD events in women.
Methods- Relevant studies in any language identified through MEDLINE (1950 to June 2009) and EMBASE (1950 to June 2009) databases.
- Studies were included if they examined a general population, measured retinal vessel caliber from retinal photographs, and documented CHD risk factors and incident CHD events.
- 6 population–based prospective cohort studies provided data for individual participant meta–analysis.
- Proportional hazards models, adjusted for traditional CHD risk factors, were constructed for retinal vessel caliber and incident CHD in women and men.
- Among 22 159 participants who were free of CHD and followed for 5 to 14 years, 2219 (10.0%) incident CHD events occurred.
- Retinal vessel caliber changes (wider venules and narrower arterioles) were each associated with an increased risk for CHD in women but not in men.
- Women without hypertension or diabetes had higher hazard ratios.
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