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Boleij A et al. – Although wild–type levels of HlpA appeared to contribute to adherence, coating of additional HlpA at the bacterial surface resulted in a reduced binding to colon tumor cells. This may be explained by the fact that heparan sulfate and LTA compete for the same binding site in HlpA. Altogether, this study implicates that HlpA serves as a fine–tuning factor for bacterial adherence.

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