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See Latest ArticlesSteroid receptor RTA activator protein (SRAP): a potential new prognostic marker for estrogen receptor-positive/node-negative/younger breast cancer patients
Breast Cancer Research, 09/14/09
Yan Y et al. – Our data suggest that SRAP levels might provide additional information on potential risk of recurrence and negative outcome in a specific set of patients with otherwise good prognosis when considering only estrogen receptor and nodal status.
Methods- Following antibody validation, SRAP expression was assessed by tissue-microarray (TMA) analysis of 372 breast tumors
- SRAP levels were significantly higher in estrogen receptor-alpha positive (ER+, n = 271), in progesterone receptor positive (PR+, n= 257) and in older patients (age > 64 years, n = 182)
- When considering ER+ tumors, PR+ tumors, or younger patients (<= 64 years), cases with high SRAP expression had a significantly worse breast cancer specific survival (BCSS) than those with low SRAP levels
- SRAP also appeared as a very powerful indicator of poor prognostic for BCSS in the subset of ER+, node negative and young breast cancer patients
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