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Chimeric IgG4 PR3-ANCA induces selective inflammatory responses from neutrophils through engagement of Fcgamma receptors
Immunology, 09/24/09

Hussain A et al. – The antibody was not able to stimulate the secretion of interleukin–8. Fc receptors were essential for neutrophil stimulation and the constitutive Fc receptors were necessary for different stimulatory pathways. The IgG4 anti–proteinase 3 antibodies are able to stimulate neutrophils to undergo a pro–inflammatory response and may play a role in the pathogenesis of small vessel vasculitis.

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