Internal Med Medical News about breast cancer risk;birth interval

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Birth intervals and breast cancer risk
British Journal of Cancer, 09/09/09

Kauppila A et al. – Short birth interval-associated excess breast cancer risk may be related to stimulatory effects of female steroid hormones produced during two closely connected pregnancies, or defective breast maturation owing to failures in breastfeeding.

Methods

The study cohort consisted of 29 488 Finnish grand multiparas, including 628 women with breast cancer

Results

Short interval (<1 year) between first and second birth increased the risk of advanced ductal breast cancer at ages < 50 years (RR=5.29; 95% CI 2.00–14.0) as compared to interval 3+ years
The risk of advanced ductal cancer was also large (RR = 4.00; 95% CI 1.19–13.4) shortly (<3 years) after last birth as compared with the period 15+ years

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