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Allred F et al. – Drinking coffee has been associated with the development of several endocrine–related cancers. The interpretation of these data has often been limited to the role that caffeine plays. Trigonelline (Trig), a niacin–related compound, is a natural constituent of coffee accounting for 1% dry matter in roasted beans...These data demonstrate that Trig even at low concentrations stimulates estrogen–dependent human breast cancer (MCF–7) cell growth and that this effect is mediated through estrogen receptor (ER), clearly identifying Trig as a novel phytoestrogen.


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