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Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration
Proceedings of the National Academy of Sciences of the United States of America, 08/26/09
Yuasa–Kawada J et al. – Slit impairs directional migration of breast cancer cells without affecting their migration speed. This inhibitory effect is Robo–mediated and USP33–dependent. These data uncover a previously unknown function of USP33 and reveal a new player in Slit–Robo signaling in cancer cell migration.
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