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Marik PE et al. – Fluid replacement is considered the cornerstone of resuscitation in the ICU. However, only about 50% of critically ill hemodynamically unstable patients are fluid responsive; furthermore, both under–resuscitation and overzealous fluid administration adversely affect outcome Consequently, the resuscitation of critically ill patients requires an accurate assessment of the patients' intravascular volume status and their volume responsiveness.

   

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