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Conventional lipid profile and lipoprotein(a) concentrations in treated patients with rheumatoid arthritis
Journal of Rheumatology, 07/02/09

García-gómez C et al. - Rheumatoid arthritis (RA) patients undergoing antirheumatic therapy display a nonatherogenic conventional lipid profile (high HDL-c, low apolipoprotein B concns, and low apolipoprotein B/apolipoprotein A-I ratio). This may be counteracted by the high prevalence of hyperlipoproteinemia(a) observed in these pts.

Methods

An evaluation of conventional lipid risk factors and lipoprotein(a) in treated RA pts
122 pts; lipid profiles of pts were compared with a control group, matched for sex, age, menopausal status, and BMI
Excess lipoprotein(a) was defined by a serum concn >0.3 g/l

Results

High-density lipoprotein cholesterol (HDL-c) concns were higher in pre- and postmenopausal women with RA vs controls
All RA pts had lower levels of apolipoprotein B and apolipoprotein B/apolipoprotein A-I ratio
Postmenopausal women with RA also had lower low-density lipoprotein cholesterol and total cholesterol levels vs controls
No differences observed in serum levels of apolipoprotein A-I and triglyceride
All RA pts had higher lipoprotein(a) values than controls
56% men and 53% and 54% pre- and postmenopausal women with RA, respectively, had hyperlipoproteinemia(a)

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