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See Latest ArticlesSerotonin transporter genotype, morning cortisol and subsequent depression in adolescents
British Journal of Psychiatry, 07/06/09
Goodyer IM et al. - The short allele of 5-HTTLPR may moderate the association between morning cortisol and the subsequent onset of a depressive episode.
Methods- High-risk adolescents (n = 403) were genotyped for 5-HTTLPR. Salivary samples were obtained on four consecutive school days within 1 h of waking from 393 (97.5%) individuals and 367 (91%) underwent a mental state reassessment at 12 months.
- Multilevel analysis revealed higher levels of salivary cortisol in short allele carriers (s/s>s/l>l/l).
- A subsequent episode of depression was increased in those with higher cortisol and the ‘s’ allele, and independently by depressive symptoms at entry, in both genders.
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