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Activation of tumor cell integrin alpha-v-beta3 controls angiogenesis and metastatic growth in the brain
Proceedings of the National Academy of Sciences of the United States of America, 07/02/09

Lorger M et al. - The authors identified a mechanism by which metastatic cells thrive in the brain microenvironment and use the high-affinity form of an adhesion receptor to grow and secure host support for proliferation. Targeting this molecular mechanism could prove valuable for the inhibition of brain metastasis.

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