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3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder
Journal of Psychiatry & Neuroscience , 07/01/09

Andreazza AC et al. - This study indicates a possible tyrosine nitration-induced damage in patients with bipolar disorder that is present from the early stage of illness. This study also indicates that patients in the late stage of illness demonstrate enhanced activity of GR and GST, which could suggest the involvement of a compensatory system in bipolar disorder.

• Matched 30 patients in the early stage and 30 patients in the late stage of bipolar disorder, diagnosed according to DSM-IV criteria, with 60 healthy controls (30 matched for each group of patients).
• Measured symptomatic status using the Hamilton Rating Scale for Depression and the Young Mania Rating Scale.

• We found a significant increase in 3-nitrotyrosine levels among patients in the early (p < 0.010) and late (p < 0.010) stages of bipolar disorder.
• The activity of GR and GST was increased only among patients in the late stage of illness.
• Glutathione peroxidase activity and carbonyl content did not differ among the groups.

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