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See Latest ArticlesTranscription factor AfPrtTp controls expression of multiple secreted proteases in the human pathogenic mold Aspergillus fumigatus
Infection and Immunity, 07/02/09
Sharon H et al. - The expression of six secreted proteases was markedly reduced. Culture filtrates from the AfPrtT-deleted strain exhibited reduced killing of lung epithelial cells and lysis of erythrocytes. However, the AfPrtT-deleted strain did not exhibit altered virulence in lung-infected mice. These results suggest that AfPrtT is not a significant virulence factor in A. fumigatus.
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