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Pulse pressure, left ventricular function and cardiovascular events during antihypertensive treatment (the LIFE study)
Blood Pressure, 07/01/09

Gerdts E et al. – During systematic antihypertensive treatment in hypertensive pts with electrocardiographic left ventricular (LV) hypertrophy, lower in-treatment pulse pressure (PP) was associated with lower in-treatment LV function and cardiac output as well as higher rate of cardiovascular events

Methods

Study of associations of in-treatment PP with LV systolic function and cardiovascular events
Subjects: 883 pts with electrocardiographic LV hypertrophy during 4.8 yrs of randomized losartan- or atenolol-based treatment
Echocardiographic substudy of the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study

Results

Both treatments similarly reduced PP
In different multiple regression models, lower in-treatment PP independently associated with lower in-treatment LV ejection fraction, stress-corrected midwall shortening, stroke volume, and cardiac index
In time-varying Cox regression models, 10 mmHg lower in-treatment PP associated with 28% higher rate of cardiovascular events
Association independent of in-treatment LV mass and ejection fraction, history of ischemic heart disease, Framingham risk score and study treatment allocation

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