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Beyond PSA: Utility of novel tumor markers in the setting of elevated PSA
Urologic Oncology: Seminars and Original Investigations, 07/01/09

Lin DW - In a review of the utility of novel tumor markers in the setting of elevated prostate-specific antigen (PSA), this article will first highlight several characteristics of an ideal biomarker, then focus on select emerging biomarkers for detection of prostate cancer (PCa).

Methods

Introduction of prostate-specific antigen (PSA) for PCa screening and detection has been used for over 20 yrs and has dramatically changed the face of PCa.
Although it is a highly sensitive serum test, its routine use has been the subject of continued controversy owing to its limited specificity.

Results

Due to this lack of specificity, many have proposed modifications of PSA in an attempt to bolster the performance of this analyte.
The human genome project and high throughput gene expression profiling has recently yielded several promising molecular biomarkers for PCa detection beyond PSA or PSA modifications.

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Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinse
BMC Cancer, 10/20/09 Relevance Score: 69%

In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer
Journal of Clinical Oncology, 10/30/09 Relevance Score: 67%

Potential predictive markers of chemotherapy resistance in stage III ovarian serous carcinomas
BMC Cancer, 10/21/09 Relevance Score: 67%

Circulating tumor cells in blood of primary breast cancer patients assessed by a novel RT-PCR test kit and comparison to status of bone marrow-disseminated tumor cells
Breast Cancer Research, 10/15/09 Relevance Score: 67%

Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: a study of 77 cases
Modern Pathology, 10/13/09 Relevance Score: 67%