Internal Med Medical News about myeloma cells

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Recommendations on the use of 18F-FDG PET in oncology

3. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

4. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease

5. Rapid correction of low vitamin D status in nursing home residents

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Dexamethasone and hypoxia upregulate CXCR4 expression in myeloma cells
Leukemia and Lymphoma, 07/02/09

Kim SW et al. - Incubation of cells under hypoxic conditions (1% O2) also induced upregulation of CXCR4 in the cytoplasm and on the cell surface and enhanced chemotaxis in response to stromal cell-derived factor-1 (SDF-1). Cell surface CXCR4 expression was more prominent in annexin V-positive apoptotic cells. Given the roles of the SDF-1/CXCR4 axis in the development and progression of myeloma, CXCR4-downregulating agents may enhance the antitumor effects of dexamethasone.

<< Previous
Alpha 4+ beta 7hiCD4+ memory T cells harbor most Th-17 cells and...

Next >>
New mutations detected by denaturing high performance liquid...