Internal Med
sponsor

Your Article Summary

See Latest Articles
(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Dexamethasone and hypoxia upregulate CXCR4 expression in myeloma cells
Leukemia and Lymphoma, 07/02/09

Kim SW et al. - Incubation of cells under hypoxic conditions (1% O2) also induced upregulation of CXCR4 in the cytoplasm and on the cell surface and enhanced chemotaxis in response to stromal cell-derived factor-1 (SDF-1). Cell surface CXCR4 expression was more prominent in annexin V-positive apoptotic cells. Given the roles of the SDF-1/CXCR4 axis in the development and progression of myeloma, CXCR4-downregulating agents may enhance the antitumor effects of dexamethasone.

Related Articles

Multiple myeloma and cutaneous anaplastic large T-cell lymphoma in the same patient: Is there a causal relation
Journal of Cutaneous Pathology, 11/09/09    Relevance Score: 67%

Initial cytoreductive treatment with thalidomide plus bolus vincristine/doxorubicin and reduced dexamethasone followed by autologous stem cell transplantation for multiple myeloma
Investigational New Drugs, 10/23/09    Relevance Score: 67%

Retrospective comparison of mobilization methods for autologous stem cell transplantation in multiple myeloma
American Journal of Hematology, 11/10/09    Relevance Score: 66%

Primary plasma cell leukemia
Cancer, 11/04/09    Relevance Score: 66%

Functional Interaction of Plasmacytoid Dendritic Cells with Multiple Myeloma Cells: A Therapeutic Target
Cancer Cell, 10/12/09    Relevance Score: 66%

Today in Clinical Pharmacology...keeping you current

Update on the efficacy, effectiveness and safety of artemether–lumefantrine combination therapy for treatment of uncomplicated malaria
Therapeutics and Clinical Risk Management, 12/20/09

How do providers assess antihypertensive medication adherence in medical encounters?
Journal of General Internal Medicine, 12/19/09

Nilotinib As Front-Line Treatment for Patients With Chronic Myeloid Leukemia in Early Chronic Phase
Journal of Clinical Oncology, 12/19/09

 See all of Clinical Pharmacology

Today in Dermatology...keeping you current

Juvenile bullous pemphigoid: the presentation and follow-up of six cases
Journal of the European Academy of Dermatology and Venereology, 12/18/09

Is there any relation between serum insulin and insulin-like growth factor-I in non-diabetic patients with skin tag
Journal of the European Academy of Dermatology and Venereology, 12/18/09

Somatostatin receptor scintigraphy in primary cutaneous T- and B-cell lymphomas
Journal of the European Academy of Dermatology and Venereology, 12/18/09

 See all of Dermatology

Today in Hematology/Oncology...keeping you current

Expression of Prostate Apoptosis Response (Par-4) Is Associated with Progesterone Receptor in Breast Cancer
Archives of Medical Research, 12/20/09

DNA Copy Number Changes in Gastric Adenocarcinomas: High Resolution–Comparative Genomic Hybridization Study in Turkey
Archives of Medical Research, 12/20/09

Evaluation of an alternative model of anticoagulant care
Irish Journal of Medical Science, 12/20/09

 See all of Hematology/Oncology