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Promoter Methylation in the Genesis of Gastrointestinal Cancer
Yonsei Medical Journal, 07/02/09
Boland CR et al. - This paper reviews the types of genetic alterations that can be found in CRCs and hepatocellular carcinoma (HCC), and focuses upon the epigenetic alterations that result in promoter methylation and the CpG island methylator phenotype (CIMP). The challenge facing CRC research and clinical care at this time is to deal with the heterogeneity and complexity of these genetic and epigenetic alterations, and to use this information to direct rational prevention and treatment strategies.
Today in Basic Science/Genetics...keeping you current
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Diagnostic challenges due to phenocopies: lessons from Multiple Endocrine Neoplasia type1 (MEN1)
Human Mutation, 12/09/09
An updated and upgraded L1CAM mutation database
Human Mutation, 12/09/09
A rare SMN2 variant in a previously unrecognized composite splicing regulatory element induces exon 7 inclusion and reduces the clinical severity of spinal muscular atrophy
Human Mutation, 12/09/09
Today in Gastroenterology...keeping you current
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A Randomized Controlled Trial of Double Versus Triple Therapy with Amantadine for Genotype 1 Chronic Hepatitis C in Latino Patients
Digestive Diseases and Sciences, 12/09/09
Prevalence of Vitamin D Deficiency in Chronic Liver Disease
Digestive Diseases and Sciences, 12/09/09
Esophageal Intraepithelial Eosinophils in Dysphagic Patients with Gastroesophageal Reflux Disease
Digestive Diseases and Sciences, 12/09/09
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Down-Regulation of miR-27a Might Reverse Multidrug Resistance of Esophageal Squamous Cell Carcinoma
Digestive Diseases and Sciences, 12/09/09
Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells
Liver International, 12/09/09
Concomitant or adjuvant temozolomide with whole-brain irradiation for brain metastases: a meta-analysis
Anti-Cancer Drugs, 12/09/09
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