Your Article Summary
See Latest ArticlesCadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance
Arteriosclerosis, Thrombosis, and Vascular Biology, 06/30/09
Messner B et al. – Research suggests cadmium (Cd) has promoting effects on early human and murine atherosclerosis, partly offset by high Zinc (Zn) concentrations.
Methods- Study of the effects of Cd in initial stages of atherosclerosis
- Subjects: 195 young healthy women of Atherosclerosis Risk Factors in Female Youngsters (ARFY) study
- Cd independently associated with early atherosclerotic vessel wall thickening (intima-media thickness >90th percentile of distribution
- In line, Cd-fed ApoE knockout mice yielded a significantly increased aortic plaque surface vs controls
- In vitro results: physiological doses of Cd increase vascular endothelial permeability up to 6-fold
- Effect by: 1) inhibition of endothelial cell proliferation, and 2) induction of a caspase-independent but Bcl-xL-inhibitable form of cell death >72 hrs after Cd addition
- Both phenomena preceded by Cd-induced DNA strand breaks and a cellular DNA damage response
- Zn showed potent protective effect against deleterious effects of Cd both in the in vitro and human studies
Related Articles
Mechanisms and consequences of efferocytosis in advanced atherosclerosis
Journal of Leukocyte Biology, 11/09/09
Relevance Score: 67%
Immune-mediated mechanisms of endothelial damage in atherosclerosis
Autoimmunity, 10/02/09
Relevance Score: 67%
Aortic Intima Media Thickness is an Early Marker of Atherosclerosis in Children with Type 1 Diabetes Mellitus
The Journal of Pediatrics, 10/30/09
Relevance Score: 66%
In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria
Kidney International, 10/27/09
Relevance Score: 66%
Prognostic Accuracy of B-Natriuretic Peptide Measurements and Coronary Artery Calcium in Asymptomatic Subjects (from the Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research [EISNER] Study)
The American Journal of Cardiology, 10/21/09
Relevance Score: 66%
Today in Atherosclerosis/Lipids...keeping you current
Receive free subspecialty "5-minute updates" via email
Low-Density Lipoprotein Cholesterol Reduction and Goal Achievement With Ezetimibe/Simvastatin Versus Atorvastatin or Rosuvastatin in Patients With Diabetes, Metabolic Syndrome, or Neither Disease, Stratified By National Cholesterol Education Program Risk Category
Metabolic Syndrome and Related Disorders, 11/25/09
Carotid Intima-Media Thickness: Knowledge and Application to Everyday Practice
Postgraduate Medicine, 11/25/09
HDL cholesterol response to growth hormone replacement is associated with common cholesteryl ester transfer protein gene variation (-629C>A) and modified by glucocorticoid treatment
European Journal of Endocrinology, 11/24/09