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Myocardial microvascular function during acute coronary artery stenosis: Effect of hypertension and hypercholesterolaemia
Cardiovascular Research, 06/30/09
Zhu XY et al. – Findings show that early exposure to the cardiovascular risk factors high-cholesterol (HC) and renovascular hypertension (HTN) protects the heart from decreases in myocardial perfusion during acute subtotal acute subtotal coronary artery obstruction (CAO). This protective effect is associated with and potentially mediated by pre-emptive development of intra-myocardial microvessels that might serve as recruitable coronary collateral arteries (CCA).
Methods- Study of whether new microvessels that proliferate in early atherosclerosis are associated with myocardial protection during acute subtotal CAO
- Induction of acute left anterior descending CAO by a balloon catheter in pigs after 12 wks of HC diet, HTN, or normal controls
- Electron beam computed tomography (CT) to assess in vivo cardiac structure, myocardial perfusion, and functional response to IV adenosine and CAO
- Micro-CT to assess ex vivo intra-myocardial microvessels
- Immunoblotting for myocardial expression of growth factors
- Basal myocardial perfusion and microvascular permeability similar among groups
- Responses to adenosine attenuated in HC and HTN
- Significant decline in myocardial perfusion in normal pigs during acute CAO attenuated in HC and abolished in HTN
- CAO elicited increase in normal anterior wall microvascular permeability, attenuated in HC and HTN
- Microvascular spatial density significantly elevated in HC and HTN, with increased myocardial growth factor expression
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Today in Atherosclerosis/Lipids...keeping you current
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Effects of Combination Lipid Therapy on Coronary Stenosis Progression and Clinical Cardiovascular Events in Coronary Disease Patients With Metabolic Syndrome: A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), and the Armed Forces Regression Study (AFREGS)
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Low bone mineral density is not associated with angiographically determined coronary atherosclerosis in men
Osteoporosis International, 12/01/09
Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review
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Today in Cardiology...keeping you current
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Effectiveness of Public Report Cards for Improving the Quality of Cardiac Care: The EFFECT Study: A Randomized Trial
JAMA, 12/02/09
Effects of Combination Lipid Therapy on Coronary Stenosis Progression and Clinical Cardiovascular Events in Coronary Disease Patients With Metabolic Syndrome: A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), and the Armed Forces Regression Study (AFREGS)
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