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See Latest ArticlesRegulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control
Proceedings of the National Academy of Sciences of the United States of America, 07/02/09
Wirnsberger G et al. - The intrinsically high predisposition of immature thymocytes to Treg development may contribute to the predominantly thymic origin of the Treg repertoire. The underlying instructive stimulus, however, does not require unique features of a dedicated APC and can be delivered by hematopoietic as well as epithelial thymic stromal cells.
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