Your Article Summary
See Latest ArticlesDose-per-fraction escalation of accelerated hypofractionated three-dimensional conformal radiotherapy in locally advanced non-small cell lung cancer
Journal of Thoracic Oncology, 07/01/09
Kepka L et al. - In a trial to determine the efficacy of accelerated hypofractionated 3-dimensional conformal radiotherapy (3D-CRT) with dose-per-fraction escalation for treatment of stage III non-small cell lung cancer (NSCLC), it appears that although dose escalation with accelerated hypofractionated 3D-CRT was limited, results and toxicity profiles obtained using this technique are promising.
Methods- 173 pts with stage III NSCLC were treated using accelerated 3D-CRT and the simultaneous boost technique.
- The total dose of 56.7 Gy (including 39.9 Gy to elective area) was delivered over 4 wks in fractions of 2.7 Gy (1.9 Gy to elective area).
- Dose-per-fraction escalation study commenced after the outcomes of 70 pts had been evaluated.
- Dose per fraction was increased from 2.7 through 2.8 Gy (level 1 escalation) to 2.9 Gy (level 2 escalation); total dose increased, respectively, from 56.7 Gy through 58.8 Gy to 60.9 Gy.
- Dose to the elective area and overall treatment time remained unchanged.
- Fit pts received 2 to 3 courses of chemotherapy before radiotherapy.
- 2- and 3-yr overall survival rates were 32% and 19%, respectively.
- Of the pts, 7% had grade III acute esophageal toxicity and 6% had grade III or greater late pulmonary toxicity.
- 2 of 9 pts who received level 2 escalation (60.9 Gy) died of pulmonary toxicity.
- The study was terminated at a dose of 58.8 Gy; this schema was adopted as institutional policy for treatment of stage III NSCLC.
Today in Hematology/Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Approach to Thrombocytopenia in Older Adults
Geriatrics & Aging, 11/10/09
Update on oral lichen planus
Expert Review of Dermatology, 10/14/09
Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer
Thyroid, 10/30/09
Today in Pulmonology...keeping you current
Receive free subspecialty "5-minute updates" via email
Management of H1N1 influenza virus respiratory syndrome
Minerva Anestesiologica, 11/11/09
Use of bisphosphonates and raloxifene and risk of deep venous thromboembolism and pulmonary embolism
Osteoporosis International, 10/30/09
Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: A meta-analysis of randomized controlled trials
Journal of Critical Care, 11/11/09
Today in Radiology/Diagnostics...keeping you current
Receive free subspecialty "5-minute updates" via email
The definition and diagnostic testing of physical and cholinergic urticarias - EAACI/GA2LEN/EDF/UNEV consensus panel recommendations
Allergy, 11/16/09
Memantine versus donepezil in mild to moderate Alzheimer's disease: a randomized trial with magnetic resonance spectroscopy
European Journal of Neurology, 11/02/09
Hemoglobin A1C and diabetes diagnosis: The Rancho Bernardo Study
Diabetes Care, 10/28/09