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Low-grade gliomas in older patients
Cancer, 07/01/09

Schomas DA et al. - The retrospective series of older patients suggests that intracranial LGG in this age group behaves aggressively. Pathologic sampling error failing to recognize higher-grade tumors does not seem to account for these poor outcomes. Aggressive management with maximally safe resection followed by adjuvant therapy should be strongly considered.

Exclusive Author Commentary
Nadia N. Laack, 07/24/09

This review looks at a rare condition in older adults. Typically survival for low-grade gliomas is 5-7 years. These outcomes suggest low grade gliomas behave aggressively in the elderly (more similar to grade 3 or higher grade tumors) and likely should be treated as such. We recommend adjuvant radiotherapy with or without temozolamide chemotherapy after maximally safe resection.

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