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Extended adjuvant hormonal therapy with exemestane has no detrimental effect on the lipid profile of postmenopausal breast cancer patients: final results of the ATENA lipid sub-study
Breast Cancer Research, 06/18/09

Markopoulos C et al. - In a study to compare the effect of exemestane on the lipid profile of postmenopausal pts with operable breast cancer in the adjuvant setting, to that of observation alone following completion of 5 to 7 yrs primary treatment with tamoxifen, it was found that exemestane lacks the beneficial effect of tamoxifen on lipids; however, sequential adjuvant treatment with exemestane in postmenopausal breast cancer pts following cessation of 5 to 7 yrs of tamoxifen does not appear to significantly alter the lipid profile vs an observational arm.

Methods

In this open-label, randomized, parallel group study, 411 postmenopausal pts with operable breast cancer who have been treated with tamoxifen for 5 to 7 yrs, were randomized to either 5 additional yrs of exemestane (25 mg/day; n=211) or observation only (n=200).
Assessments of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and total serum triglycerides (TRG) were performed at baseline and then during each follow up visit, performed at either 6 or 12 mos according to the center's clinical practice, until completing 24 mos in the study.

Results

TC and LDL levels increased significantly across time for both arms; TC increase was more pronounced for the observation arm and that was sustained up to 24 mos.
HDL levels decreased significantly across time for the exemestane arm, while no significant change was detected across time for the observation arm.
Triglyceride levels decreased significantly across time on both arms with no difference detected in changes from baseline between exemestane and observation arm.

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