Internal Med Medical News about increased risk of myocardial infarction;genetically elevated lipoprotein

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Recommendations on the use of 18F-FDG PET in oncology

3. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

4. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease

5. Rapid correction of low vitamin D status in nursing home residents

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction
JAMA, 06/11/09

Kamstrup PR et al. – Findings are consistent with a causal association between elevated lipoprotein(a) levels and increased risk of myocardial infarction (MI).

Methods

Study of whether genetic data are consistent with a causal association between elevated lipoprotein(a) levels and increased risk of MI
Evaluation of 3 studies of white pts from Copenhagen, Denmark
Copenhagen City Heart Study (CCHS): prospective general population study with 16-yr follow-up (1991-2007, n = 8,637,599 MI events)
Copenhagen General Population Study (CGPS): cross-sectional general population study (2003-2006, n = 29,388,994 MI events)
Copenhagen Ischemic Heart Disease Study (CIHDS): case-control study (1991-2004, n = 2461,1231 MI events)
Main outcome measures: Plasma lipoprotein(a) levels, lipoprotein(a) kringle IV type 2 (KIV-2) size polymorphism genotype, and MIs from 1976- 2007 for all pts

Results

Genetically elevated lipoprotein(a) was associated with an HR of 1.22 per doubling of lipoprotein(a) level on instrumental variable analysis; corresponding value for plasma lipoprotein(a) levels on Cox regression was 1.08

<< Previous
New approaches in the management of insomnia: weighing the...

Next >>
Denosumab update